2. Efficacy and safety of needle free jet injector assisted intralesional treatments in dermatology—a systematic review. 44 treatment of alopecia areata resulted in bleeding from the arteria temporalis in one patient, which was controlled by firm pressure.32 Methodological quality assessment Overall risk of bias assessed with Cochrane’s ROB 2.0 tool was “high” in six RCTs and CCTs, “some concerns” in four studies, and “low” in two studies (Fig. 2a). Methodological quality was particularly poor due to deviations from the intended intervention and selection bias (Fig. 2b).
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