2. Efficacy and safety of needle free jet injector assisted intralesional treatments in dermatology—a systematic review. 46 According to the Newcastle–Ottawa Scale, overall risk of bias in the included cohorts and case series was “high” in eleven, “some concerns” in another eleven, and “low” in three studies (Fig. 3a).16 Methodological quality was particularly poor due to lack of comparative cohorts, lack of blinding, and short follow-up time (Fig. 3b).
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