TABLE OF CONTENTS Chapter 1 General introduction 9 Section I Needle-free jet injectors in dermatology Chapter 2 Efficacy and safety of needle-free jet injector-assisted intralesional 37 treatments in dermatology—a systematic review Section II Biodistribution using different injection techniques in severe keloids and properties of severe keloids Chapter 3 Biodistribution of needle-injections and needle-free jet-injectors 73 visualized by a 3D- Fluorescent Imaging Cryomicrotome System Chapter 4 Effects of keloid properties on treatment efficacy 95 Section III Efficacy and safety of intralesional bleomycin treatment in severe keloids Chapter 5 Needle-free electronically-controlled jet injector treatment with 115 bleomycin is efficacious and well-tolerated in patients with severe keloids: results of a randomized, double-blind, placebo-controlled trial Chapter 6 Needle-free electronically-controlled jet injector treatment with 145 bleomycin and lidocaine is effective and well-tolerated in patients with recalcitrant keloids Section IV Needle-free jet injector assisted treatment in children with keloids and hypertrophic scars Chapter 7 Needle-free jet Injector-assisted triamcinolone treatment of keloids and 177 hypertrophic scars is effective and well tolerated in children
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