3. Biodistribution of needle-injections and needle-free jet-injections visualized by a 3D- Fluorescent Imaging Cryomicrotome System 84 Figure 4B. 3D images of segmented fluorescent regions representing the TCA volume using needles in keloid samples (16 to 27), and normal skin (28 to 30) Clinical endpoints jet injections The residual TCA volume on the skin surface after jet injections was high, especially in keloids (Table 2). Using higher pressure of 6 Bar seems to result in larger fluorescent TCA volumes in keloids, compared to lower pressures (Table 2). Contradictory, higher pressure also resulted in larger residual volumes in our experiments. Papule formation was observed in 66% (6/9) of the keloid samples, while this was observed in all (6/6) normal skin samples. No clear relation was observed between papule formation in keloids and mean fluorescent TCA volume. 28 Normal skin 29 Normal skin 30 Normal skin
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