Vazula Bekkers

Chapter 1 General introduction 9
Section I Needle-free jet injectors in dermatology 35
Chapter 2 Efficacy and safety of needle-free jet injector-assisted intralesional treatments in dermatology —a systematic review 37
Section II Biodistribution using different injection techniques in severe keloids and properties of severe keloids 71
Chapter 3 Biodistribution of needle-injections and needle-free jet-injectors visualized by a 3D- Fluorescent Imaging Cryomicrotome System 73
Chapter 4 Effects of keloid properties on treatment efficacy 95
Section III Efficacy and safety of intralesional bleomycin treatment in severe keloids 113
Chapter 5 Needle-free electronically-controlled jet injector treatment with bleomycin is efficacious and well-tolerated in patients with severe keloids: results of a randomized, double-blind, placebo-controlled trial 115
Chapter 6 Needle-free electronically-controlled jet injector treatment with bleomycin and lidocaine is effective and well-tolerated in patients with recalcitrant keloids 145
Section IV Needle-free jet injector assisted treatment in children with keloids and hypertrophic scars 175
Chapter 7 Needle-free jet Injector-assisted triamcinolone treatment of keloids and hypertrophic scars is effective and well tolerated in children 177
Chapter 8 General discussion 199
Chapter 9 English and Dutch summaries 219
Chapter 10 Appendices 229
Abbreviations 230
List of co-authors 231
List of publications 235
About the author 237
PhD portfolio 238
Dankwoord 241

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