124 Chapter 3 TRIP database We searched the TRIP database on January 15th, 2021, with the following search strings: - (cough or pneumonia [anywhere in the document]) and (CRP or protein or biomarker [anywhere in the document]), from: 2016 to: 2020, area: ‘Primary care’; filter on guidelines. This resulted in 40 hits. Application of the eligibility criteria on this result, led to the exclusion of all 40 hits. - (colonoscopy [anywhere in the document]), from: 2016 to: 2020; filter on guidelines. This resulted in 192 hits. Application of the eligibility criteria on this result, led to the exclusion of 187 hits. We included five CPGs in the final analysis [1, 5, 9-11]. Medline We searched the Medline database, using Ovid Silverplatter on January 16th, 2021, with the following search strings: - (cough OR pneumonia [Title]) AND (guideline* OR recommendation* [Title]). We limited the search results to publication years 2016-2020, and publications in English, German, or Dutch language. This resulted in 132 hits. - (colorectal or (colon adj3 cancer) or (colon adj3 carcinoma) or colonoscopy [Title] AND (guideline* OR recommendation* [Title]. We limited the search results to publication years 2016-2020, and publications in English, German, or Dutch language. This resulted in 269 hits. Screening of the results in the cough/pneumonia search resulted in the selection of 11 abstracts about cough/pneumonia and 11 abstracts about colonoscopy. These abstracts were studied in full-text CPGs. This led to the inclusion of three CPGs about cough/pneumonia [12-14], and three CPGs about colonoscopy [1, 5, 15]. The reasons for exclusion are stated in tables 2 and 3. Table 2. List of excluded studies about CRP First author, year of publication Reason for exclusion Cao, 2018 [16] No recommendation about CRP testing Correa, 2018 [12] No recommendation about CRP testing Grief, 2018 [17] No recommendation about CRP testing Jones, 2020 [18] No recommendation about CRP testing Kardos, 2019 [19] No recommendation about CRP testing Metlay, 2019 [20] No recommendation about CRP testing Moore, 2019 [21] No recommendation about CRP testing Wiersinga, 2018 [22] No recommendation about CRP testing as a diagnostic test Wilkes, 2016 [23] No recommendation about CRP testing
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