Mariska Tuut

136 Chapter 3 Other aspects of the quality of the guideline Patient involvement: The views and preferences of the target population (patients, public, etc.) have been sought See https://www.agreetrust.org/wpcontent/uploads/2017/12/AGREE-II-Users-Manual-and-23-itemInstrument-2009-Update-2017.pdf page 17 for guidance on this question  1 – Strongly disagree  2  3  4  5  6  7 – Strongly agree Methodologist involvement This information can be found in the information about the CPG panel, in the introduction or methods section of the guideline, or in general information of the developer  Yes, in CPG panel  No, not in CPG panel, but at bureau level or in technical team, etc  No involvement  Unclear The evidence-base of the recommendation This information can be found in the text or conclusions that are the basis of the recommendation Diagnostic accuracy Defined as information about sensitivity, specificity, predictive values, false positives, false negatives, etc. Did the authors report diagnostic accuracy?  Yes  No  skip next two questions  Unclear If the answer on the previous question is YES: Is the information about diagnostic accuracy based on a systematic review of the literature?  Yes  No  skip next question  Unclear If the answer on the previous question is YES: Is the quality of the evidence about diagnostic accuracy assessed?  Yes  No  Unclear Test burden Defined as side effects of the test, complications of the test Did the authors report test burden?  Yes  No  skip next two questions  Unclear If the answer on the previous question is YES: Is the information about test burden based on a systematic review of the literature?  Yes  No  skip next question  Unclear If the answer on the previous question is YES: Is the quality of the evidence about test burden assessed?  Yes  No  Unclear Natural course This is important to judge the value of the test, e.g. in case of mild natural course or a large proportion of false negative test results Did the authors report natural course of the disease?  Yes  No  skip next two questions  Unclear

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