Clinical practice guidelines & test consequences 137 3 If the answer on the previous question is YES: Is the information about natural course based on a systematic review of the literature? Yes No skip next question Unclear If the answer on the previous question is YES: Is the quality of the evidence about natural course assessed? Yes No Unclear Effectiveness of disease management E.g. treatment/therapy Did the authors report effectiveness of disease management in the evaluation of the test? Yes No skip next two questions Unclear If the answer on the previous question is YES: Is the information about effectiveness of disease management based on a systematic review of the literature? Yes No skip next question Unclear If the answer on the previous question is YES: Is the quality of the evidence about effectiveness of disease management assessed? Yes No Unclear Linked evidence Defined as the link between test result and patient outcomes, expressed in studies that link diagnostic accuracy outcome measures (TP, FP, TN, FN) to patient important outcomes (eventually covered in the overall certainty in the evidence) Did the authors report 'linked evidence'? Yes No Unclear Final remarks Narrative
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