Required knowledge 157 4 - Test-treatment pathway: Test consequences Target patient/ population Clinical uncertainty Diagnosis Change in clinical decisions Test burden Intermediate outcome Adverse events of treatment/other tests Change in patient relevant outcomes Testing Testing Decision making Treatment Association Other tests Figure 1. Schematic test-treatment pathway (adapted from Harris et al.) [7] Brief description of this study We created a draft list of knowledge components required to adequately develop diagnostic test recommendations. We reviewed current evidence, such as existing guideline competency frameworks, methodological literature about the evaluation of medical tests and clinical practice guidelines, and handbooks about test evaluation and clinical guideline development. The next steps are review of the draft list by experts in the field of diagnostic test evaluation and guideline development and interviews of these experts. The results of the interviews will be incorporated in a new version of the list with knowledge components. This list will be sent out in an internet survey to a broader group, in which participants will be asked to score each knowledge component per role (health care provider, health care consumer representative, methodologist, guideline panel chair) in the clinical guideline panel. Interviews We plan to interview experts in the field who are specialized in specific domains: - Diagnostic process in clinical practice - Diagnostic test evaluation - Clinical practice guideline development and GRADE for medical tests - Patient involvement in clinical practice guideline development - Training about clinical guideline development concerning medical tests Interview items Please note: - The focus of this study is specifically on the development of diagnostic test recommendations in clinical guideline development. General competencies
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