34 Chapter 2 Figure 1a. Literature search and selection of the sub-questions (diagnostic accuracy, test burden, linked evidence) Identification Screening Eligib ili ty Included Diagnostic accuracy Medline search n = 391 Embase search n = 722 Total number of records n = 1113 Title and abstract screening Records excluded n = 1096 Full-text articles Assessed for eligibility n = 17 Full-text articles exluded with reasons n = 14. - no IgE-testing (n=5) - no provocation test (n=2) - sensitivity and speci fici ty cannot be determined (n=5) - only patients included with positive IgEtest (n=1) - none of the selected allergens (n=1) Included in evidence synthesis n = 3 Test burden Medline search n = 62 Embase search n = 148 Total number of records n = 210 Title and abstract screening Records excluded n = 202 Full-text articles Assessed for eligibility n = 8 Full-text articles exluded with reasons n = 8. - no systematic review (n=4) - none of the selected outcomes (n=1) - only description of effect of intervention to reduce pain, no report on pain caused by venipunction itself (n=2) - full-text not available (n=1) Included in evidence synthesis n = 0 Linked evidence Medline search n = 256 Embase search n = 235 Total number of records n = 491 Title and abstract screening Records excluded n = 470 Full-text articles Assessed for eligibility n = 21 Full-text articles exluded with reasons n = 14 - not about allergic rhinitis (n=1) - conference abstract (n=3). - no systematic research (n=5) - patients with asthma not separately analysed (n=1) - no information about outcomes (n=4) Included in evidence synthesis n = 7
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