58 Chapter 2 Describe included patients (prior testing, intended use of index test and setting) Patients presented at university clinic with clinically assumed house dust mite allergy Is there concern that the included patients do not match the review question? CONCERN: LOW/HIGH/UNCLEAR This systematic review focusses on patients with suspected allergic rhinitis in primary care. It is not clear whether this is similar to the patients in this study. Domain 2: Index test A. Risk of bias Describe the index test and how it was conducted and interpreted See above Were the index test results interpreted without knowledge of the results of the reference standard? Yes/no/unclear If a threshold was used, was it pre-specified? Yes/no/unclear Could the conduct or interpretation of the index test have introduced bias? RISK: LOW/HIGH/UNCLEAR B. Concerns regarding applicability Is there concern that the index test, its conduct, or interpretation, differ from the review question? CONCERN: LOW/HIGH/UNCLEAR Domain 3: Reference standard A. Risk of bias Describe the reference standard and how it was conducted and interpreted See above Is the reference standard likely to correctly classify the target condition? Yes/no/unclear Were the reference standard results interpreted without knowledge of the results of the index test? Yes/no/unclear Could the reference standard, its conduct, or its interpretation have introduced bias? RISK: LOW/HIGH/UNCLEAR B. Concerns regarding applicability Is there concern that the target condition as defined by the reference standard does not match the review question? CONCERN: LOW/HIGH/UNCLEAR Domain 4: Flow and timing A. Risk of bias Describe any patients who did not receive the index test(s) and/or reference standard or who were excluded from the 2x2 table Retrospective analysis: excluded patients were not mentioned
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