70 Chapter 2 Did the review authors provide a list of excluded studies and justify the exclusions? For Partial Yes: provided a list of all potentially relevant studies that were read in full-text form but excluded from the review For Yes, must also have: Justified the exclusion from the review of each potentially relevant study Yes Partial yes No Did the review authors describe the included studies in adequate detail? For Partial Yes (ALL the following): described populations described interventions described comparators described outcomes described research designs For Yes, should also have ALL the following: described population in detail described intervention in detail (including doses where relevant) described comparator in detail (including doses where relevant) described study’s setting timeframe for follow-up Yes Partial yes No Did the review authors use a satisfactory technique for assessing the risk of bias (RoB) in individual studies that were included in the review? RCTs For Partial Yes, must have assessed RoB from unconcealed allocation, and lack of blinding of patients and assessors when assessing outcomes (unnecessary for objective outcomes such as allcause mortality) For Yes, must also have assessed RoB from: allocation sequence that was not truly random, and selection of the reported result from among multiple measurements or analyses of a specified outcome Yes Partial Yes No Includes only NRSI NRSI For Partial Yes, must have assessed RoB: from confounding, and from selection bias For Yes, must also have assessed RoB: methods used to ascertain exposures and outcomes, and selection of the reported result from among multiple measurements or analyses of a specified outcome Yes Partial Yes No Includes only RCTs Did the review authors report on the sources of funding for the studies included in the review? For Yes Must have reported on the sources of funding for individual studies included in the review. Note: Reporting that the reviewers looked for this information but it was not reported by study authors also qualifies Yes No If meta-analysis was performed did the review authors use appropriate methods for statistical combination of results? RCTs For Yes: The authors justified combining the data in a meta-analysis AND they used an appropriate weighted technique to combine study results and adjusted for heterogeneity if present. AND investigated the causes of any heterogeneity Yes No No meta-analysis conducted
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