Applying GRADE for diagnosis 73 2 justified publication restrictions (e.g. language) For yes, should also have (all the following): searched the reference lists/bibliographies of included studies searched trial/study registries included/consulted content experts in the field where relevant, searched for grey literature conducted search within 24 months of completion of the review Yes Partial yes No Did the review authors perform study selection in duplicate? For yes, either one of the following: at least two reviewers independently agreed on selection of eligible studies and achieved consensus on which studies to include OR two reviewers selected a sample of eligible studies and achieved good agreement (at least 80%), with the remainder selected by one reviewer Yes No Did the review authors perform data extraction in duplicate? For yes, either ONE of the following: at least two reviewers achieved consensus on which data to extract from included studies OR two reviewers extracted data from a sample of eligible studies and achieve good agreement (at least 80 percent), with the remainder extracted by one reviewer Yes No Did the review authors provide a list of excluded studies and justify the exclusions? For Partial Yes: provided a list of all potentially relevant studies that were read in full-text form but excluded from the review For Yes, must also have: Justified the exclusion from the review of each potentially relevant study Yes Partial yes No Did the review authors describe the included studies in adequate detail? For Partial Yes (ALL the following): described populations described interventions described comparators described outcomes described research designs For Yes, should also have ALL the following: described population in detail described intervention in detail (including doses where relevant) described comparator in detail (including doses where relevant) described study’s setting timeframe for follow-up Yes Partial yes No Did the review authors use a satisfactory technique for assessing the risk of bias (RoB) in individual studies that were included in the review? RCTs For Partial Yes, must have assessed RoB from unconcealed allocation, and lack of blinding of patients and assessors when
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