Applying GRADE for diagnosis 75 2 If meta-analysis was performed, did the review authors assess the potential impact of RoB in individual studies on the results of the metaanalysis or other evidence synthesis? For Yes: included only low risk of bias RCTs OR, if the pooled estimate was based on RCTs and/or NRSI at variable RoB, the authors performed analyses to investigate possible impact of RoB on summary estimates of effect. Yes No No meta-analysis conducted Did the review authors account for RoB in individual studies when interpreting/ discussing the results of the review? For Yes: included only low risk of bias RCTs OR, if RCTs with moderate or high RoB, or NRSI were included the review provided a discussion of the likely impact of RoB on the results Yes No Did the review authors provide a satisfactory explanation for, and discussion of, any heterogeneity observed in the results of the review? For Yes: There was no significant heterogeneity in the results OR if heterogeneity was present the authors performed an investigation of sources of any heterogeneity in the results and discussed the impact of this on the results of the review Yes No If they performed quantitative synthesis did the review authors carry out an adequate investigation of publication bias (small study bias) and discuss its likely impact on the results of the review? For Yes: performed graphical or statistical tests for publication bias and discussed the likelihood and magnitude of impact of publication bias Yes No No meta-analysis conducted Did the review authors report any potential sources of conflict of interest, including any funding they received for conducting the review? For Yes: The authors reported no competing interests OR The authors described their funding sources and how they managed potential conflicts of interest Yes No Penagos, 2008 [8] Author Penagos Year of publication 2008 Journal Allergy Study design Systematic review Study population 16 double-blind RCTs including 2998 children and adults with seasonal or persistent allergic rhinitis Description of the intervention (including dosage and duration) Mometaosone furoate nasal spray 100 or 200 µg Description of control group Compared to placebo for this review Outcome measures Total nasal symptom score (TNSS), nasal individual symptom scores (congestion, rhinorrhoea, sneezing, nasal itching), non-nasal symptom scores (ocular, otic, palate and throat complaints, cough, etc.), nasal airflow, adverse events frequency Effect on outcome measures (nasal / ocular symptoms, concentration, sleep problems, absenteeism from school / work, quality of life) Total nasal symptom score (TNSS): SMD: -0.56 (95%CI: -0.71 to -0.41) (10 studies in adults, 1878 patients); sub-analysis due to heterogeneity, of studies that assessed the post-challenge effect on TNSS: SMD: -0.33 (95%CI: -0.50 to -0.17). 1 study in children: SMD: - 0.41 (95%CI: -0.65 to -0.17) (n=271). Individual nasal symptom scores:
RkJQdWJsaXNoZXIy MTk4NDMw