Applying GRADE for diagnosis 77 2 Yes No Did the review authors perform data extraction in duplicate? For yes, either ONE of the following: at least two reviewers achieved consensus on which data to extract from included studies OR two reviewers extracted data from a sample of eligible studies and achieve good agreement (at least 80 percent), with the remainder extracted by one reviewer Yes No Did the review authors provide a list of excluded studies and justify the exclusions? For Partial Yes: provided a list of all potentially relevant studies that were read in full-text form but excluded from the review For Yes, must also have: Justified the exclusion from the review of each potentially relevant study Yes Partial yes No Did the review authors describe the included studies in adequate detail? For Partial Yes (ALL the following): described populations described interventions described comparators described outcomes described research designs For Yes, should also have ALL the following: described population in detail described intervention in detail (including doses where relevant) described comparator in detail (including doses where relevant) described study’s setting timeframe for follow-up Yes Partial yes No Did the review authors use a satisfactory technique for assessing the risk of bias (RoB) in individual studies that were included in the review? RCTs For Partial Yes, must have assessed RoB from unconcealed allocation, and lack of blinding of patients and assessors when assessing outcomes (unnecessary for objective outcomes such as allcause mortality) For Yes, must also have assessed RoB from: allocation sequence that was not truly random, and selection of the reported result from among multiple measurements or analyses of a specified outcome Yes Partial Yes No Includes only NRSI NRSI For Partial Yes, must have assessed RoB: from confounding, and from selection bias For Yes, must also have assessed RoB: methods used to ascertain exposures and outcomes, and selection of the reported result from among multiple measurements or analyses of a specified outcome Yes Partial Yes No Includes only RCTs Did the review authors report on the sources of funding for the studies included in the review? For Yes
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