84 Chapter 2 Setting Population-based, Germany Study population Baseline 1995-1996: 6399 fourth grade class children, population-based sample. 85% answered questionnaire. Number at follow-up 2002-2003: 4893 adolescents aged 15-18 yrs; 77% answered questionnaire. Only persons of German descent were analysed. Outcome measures (nasal / ocular symptoms, concentration, sleep problems, absenteeism from school / work, quality of life) Symptoms (sneezing/runny nose/blocked nose, itchy/watery eyes): 64% retained symptoms at follow-up. Follow-up:7 yrs Risk of bias (tailormade criteria) Primary Was there a representative sample of patient (who were at a similar, identifiable, common, and possible early point in the course of the disease)? Yes/no/unclear Was follow-up sufficiently long and complete? Yes/no/unclear Secondary Were objective and unbiased outcome criteria used? Yes/no/unclear Were all characteristics of patients known or suspected to affect the outcome recorded (e.g. comorbidity) Yes/no/unclear Was there adjustment for important prognostic factors (e.g. information about treatment)? Yes/no/unclear Kong, 2012 [13] Author Kong Year of publication 2012 Journal American Journal of Rhinology & Allergy Study design Follow-up study Setting Population-based, China Study population Baseline: 1211 3-6 yrs old children in Wuhan, China, of whom 328 symptom positive (27.1%). Number at follow-up: 870 children (71.8%), of whom 256 symptom positive (29.4%). Outcome measures (nasal / ocular symptoms, concentration, sleep problems, absenteeism from school / work, quality of life) From children symptom positive at baseline (n=328), 149 remained symptom positive (45%). Follow-up: 5 yrs Risk of bias (tailormade criteria) Primary Was there a representative sample of patient (who were at a similar, identifiable, common, and possible early point in the course of the disease)? Yes/no/unclear Was follow-up sufficiently long and complete? Yes/no/unclear Secondary Were objective and unbiased outcome criteria used? Yes/no/unclear Were all characteristics of patients known or suspected to affect the outcome recorded (e.g. comorbidity) Yes/no/unclear Was there adjustment for important prognostic factors (e.g. information about treatment)? Yes/no/unclear Lee, 2016 [14] Author Lee Year of publication 2016 Journal Clinical and Experimental Otorhinolaryngology Study design Prospective cohort study Setting Public school, Seoul, South-Korea
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