98 Chapter 2 Natural course Question: Course of nasal and ocular symptoms in patient with confirmed allergic rhinitis over the years Bibliography: Di Lorenzo, 2013; Greisner, 1998; Kellberger, 2012; Kong 2012; Lee, 2016; Westman, 2012; Yonekura, 2012 [11-17] a. Some of the included studies had a quite short follow-up, some of the studies had a large proportion lostto-follow-up, most of the studies did not report comorbidity and medication use (and it is unlikely that participants did not use medication at all) b. Large heterogeneity, which cannot be explained by differences in patient population, intervention or followup c. It is assumed that the participants in the study use medication Certainty assessment Effect Certainty № of studies Study design Risk of bias Inconsistency Indirectness Imprecision Other considerations № of events № of individuals Rate (95% CI) Remission (follow up: range 2 years to 23 years) 7 Observational studies very seriousa seriousb seriousc serious none 1272% 8986 ⨁◯◯◯ VERY LOW Fewer symptoms or remission (follow up: range 16 years to 23 years) 2 Observational studies seriousa not serious seriousc serious none 4655% 1129 ⨁◯◯◯ VERY LOW
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