Composite versus individual biomarkers for predicting clinical benefit to PD-1 blockade in NSCLC 121 3 PD-L1 TPS (%) TIS score CD8 TILs+ IT CD8 T cells (probability score, DC 6m) CD3 TILs+ IT CD8 T cells (probability score, DC 6m) CD8 TILs+ TIS (probability score, DC 12m) CD8 TILs+ IT CD8 T cells (probability score, DC 12m) 30 7.25 0.2118835 0.2109187 0.0463233 0.137822 0 NA 0.0744299 0.1140751 NA 0.0449534 0 5.48 NA NA NA NA 20 9.03 0.7950019 0.6614375 0.3327138 0.6185755 0 5.4 NA NA NA NA PPV NPV AUC AUC 95% CI lower limit AUC 95% CI upper limit 58 96 85 73 97 58 96 85 74 97 58 96 86 72 99 58 96 86 70 100 55 95 85 72 98 55 95 82 68 95 55 95 84 71 97 50 96 83 73 94 47 100 83 67 99 47 100 82 67 98 47 100 81 65 98 47 100 84 69 100 47 95 78 65 92 44 94 82 68 97 45 95 73 59 88 45 95 72 58 87 44 100 86 72 100 44 100 84 68 100 44 95 71 56 86 42 100 89 74 100
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