Chapter 3 122 Table S2. Continued Model Sensitivity ≥90% Specificity Specificity 95% CI lower limit Specificity 95% CI upper limit PD-L1 * TIS 1.00 45 23 68 CD8 * LA 0.94 41 25 58 PD-L1 * IT-CD8 0.94 38 23 55 TLS * CD3 0.94 38 22 55 LA * CD3 0.94 38 22 55 CD20 * CD3 0.94 38 22 55 PD-L1 * CD3 0.94 35 20 53 CD3 0.94 35 20 53 CD8 * TLS 0.94 35 20 53 CD8 * CD20 0.94 32 18 50 PD-L1 * CD20 0.94 32 18 50 CD8 * CD3 0.94 32 18 50 CD8 0.94 28 15 45 PD-L1 * CD8 0.94 26 13 42 CD8 TILs * TIS 1.00 25 9 49 PD-L1 * LA 0.94 24 12 41 TLS * IT-CD8 0.94 8 2 22 LA * IT-CD8 0.94 8 2 22 CD20 * IT-CD8 0.94 8 2 22 IT-CD8 0.94 8 2 21 TLS * LA 1.00 3 0 14 PD-L1 1.00 0 0 9 TLS 1.00 0 0 9 LA 1.00 0 0 9 PD-L1 * TLS 1.00 0 0 9 NA, not available
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