Chapter 3 124 Table S3. Predictive accuracy of individual and composite biomarkers at a prespecified criterium of ≥90% sensitivity for detecting disease control (DC) at 12 months in the training cohort. * Indicates an interaction term. Model Sensitivity ≥90% Specificity Specificity 95% CI lower limit Specificity 95% CI upper limit PD-1T * CD8 1.00 73 54 87 PD-1T * CD3 1.00 70 51 84 PD-1T * TLS 1.00 70 51 84 CD8 * TIS 1.00 68 45 86 PD-1T 1.00 67 48 82 PD-1T * CD20 1.00 67 48 82 PD-1T * LA 1.00 67 48 82 PD-1T * PD-L1 1.00 67 48 82 CD8 * IT-CD8 0.92 63 47 77 CD3 * IT-CD8 0.92 59 42 74 LA * IT-CD8 0.92 56 40 72 PD-L1 * CD8 0.92 56 40 71 PD-1T * TIS 1.00 55 32 76 CD8 * LA 0.92 54 37 69 PD-1T * IT-CD8 1.00 52 34 69 CD3 * TIS 1.00 50 28 72 LA * TIS 1.00 50 28 72 TIS 1.00 50 28 72 CD-20 * IT-CD8 0.92 49 33 65 TLS * CD20 0.92 49 33 65 TLS * IT-CD8 0.92 49 33 65 CD20 * CD3 0.92 46 31 63 CD20 * TIS 1.00 45 24 68 IT-CD8 * TIS 1.00 45 24 68 TLS * TIS 1.00 45 24 68 CD20 0.92 44 28 60 IT-CD8 0.92 44 29 60 PD-L1 * IT-CD8 0.92 42 27 58 CD8 * CD3 0.92 41 26 58 CD8 * TLS 0.92 41 26 58 PD-L1 * CD3 0.92 41 26 58 PD-L1 * TIS 1.00 41 21 64 TLS * CD3 0.92 41 26 58 CD3 0.92 39 24 55
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