General introduction and thesis outline 17 1 In Chapter 6 we describe the diagnostic yield of cell free DNA (cfDNA) extracted from pleural effusion as an alternative bio-source for molecular profiling of tumors. Currently, molecular analysis has become the mainstay in diagnostics to guide treatment selection and monitoring in advanced NSCLC. This study highlights the potential of cfDNA analysis in pleural effusion, even when tumor cell purity is low. Last, chapter 7 presents a general discussion of all chapters, providing a holistic view of the research findings and their implications.
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