Chapter 5 200 4. Multivariate analysis of the development cohort Supplementary Table S13: Multivariate analysis of OS and PFS for the development cohort by test classification resistant vs. not resistant. OS PFS HR (95% CI) P value HR (95% CI) P value Test classification (not resistant vs. resistant) 0.59 (0.34-1.03) 0.062 0.53 (0.32-0.89) 0.015 ECOG PS (1 vs. 0) 1.71 (0.90-3.22) 0.100 1.36 (0.78-2.35) 0.277 ECOG PS (≥2 vs. 0) 4.67 (2.05-10.66) <0.001 2.50 (1.19-5.25) 0.016 Never vs. ever smoker 1.88 (0.84-4.23) 0.126 1.20 (0.54-2.65) 0.657 Squamous vs. non-squamous 1.02 (0.56-1.84) 0.960 1.04 (0.62-1.76) 0.876 PD-L1 (<1% vs. ≥1%) 1.53 (0.79-2.95) 0.205 1.40 (0.76-2.58) 0.285 PD-L1 (NA vs. ≥1%) 0.85 (0.41-1.77) 0.669 0.86 (0.45-1.65) 0.655 Supplementary Table S14: Multivariate Analysis of OS and PFS for the development cohort by test classification sensitive vs. not sensitive. OS PFS HR (95% CI) P value HR (95% CI) P value Test classification (sensitive vs. not sensitive) 0.60 (0.30-1.20) 0.150 0.63 (0.35-1.15) 0.132 ECOG PS (1 vs. 0) 1.64 (0.86-3.13) 0.133 1.39 (0.80-2.40) 0.245 ECOG PS (≥2 vs. 0) 4.80 (2.11-10.91) <0.001 2.68 (1.28-5.57) 0.009 Never vs. ever smoker 2.14 (0.92-4.95) 0.077 1.31 (0.58-2.95) 0.512 Squamous vs. non-squamous 0.99 (0.55-1.81) 0.988 1.05 (0.62-1.78) 0.856 PD-L1 (<1% vs. ≥1%) 1.65 (0.86-3.14) 0.130 1.66 (0.92-2.99) 0.091 PD-L1 (NA vs. ≥1%) 1.02 (0.50-2.07) 0.958 1.08 (0.57-2.04) 0.811
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