Serum test identifies patients deriving benefit from CPIs 207 5 Supplementary Figure 8: Dot plot of PD-L1 staining by test classification in the pooled analysis of second line patients with known staining. Less than 1% is shown as 0. Whiskers show minimum and maximum. Boxes show the median and quartiles. Median and first quartile are both 0% for resistant and intermediate. Median and first quartile are 0% and 0.5% for sensitive. 11. Additional Univariate and Multivariate Analyses of the Pooled Second-Line Cohort Supplementary Table 20: Cox proportional hazards analyses stratified by cohort with test classification and PD-L1 status as explanatory variables. OS PFS Analysis 1 HR (95% CI) P value HR (95% CI) P value Test Classification (vs. resistant) not resistant 0.50 (0.36-0.70) <0.001 0.60 (0.44-0.81) 0.001 PD-L1 (vs. positive) negative 1.51 (0.95-2.40) 0.081 1.52 (1.00-2.29) 0.049 NA 0.96 (0.62-1.50) 0.861 0.92 (0.62-1.37) 0.681 Analysis 2 HR (95% CI) P value HR (95% CI) P value Test Classification (vs. not sensitive) sensitive 0.54 (0.36-0.80) 0.002 0.66 (0.47-0.92) 0.015 PD-L1 (vs positive) negative 1.53 (0.96-2.43) 0.072 1.55 (1.03-2.35) 0.037 NA 1.09 (0.70-1.69) 0.717 1.01 (0.69-1.50) 0.951
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