Serum test identifies patients deriving benefit from CPIs 209 5 14. Protein set enrichment analysis of association of biological processes with test classification sensitive vs. not sensitive Supplementary Table 21: PSEA for association of biological processes with test classification sensitive vs. not sensitive Biological Process P value of association FDR Immune tolerance and suppression 0.0035 <0.1 Acute inflammatory response 0.0154 <0.2 Acute phase response 0.0170 <0.2 Cytokine production involved in immune response 0.0665 <0.4 Complement activation 0.1372 <0.5 Innate immune response 0.1523 <0.5 Angiogenesis 0.1532 <0.5 NK cell mediated immunity 0.1717 <0.5 B cell mediated immunity 0.2683 <0.7 Wound healing 0.2760 <0.7 Type 2 immune response 0.3887 <0.8 Extra cellular matrix 0.4302 <0.8 Epithelial-Mesenchymal Transition 0.4332 <0.8 Chronic Inflammatory response 0.5087 <0.8 IFN type 1 0.5488 <0.8 IFN-Gamma 0.5558 <0.8 Type 17 immune response 0.5576 <0.8 Response to hypoxia 0.5601 <0.8 Cellular component morphogenesis 0.6322 <0.8 T cell mediated immunity 0.6769 <0.8 Type 1 immune response 0.7802 <0.9 Glycolysis and positive regulators 0.8013 <0.9 Behavior 0.8487 <0.9
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