Cell-free DNA in the supernatant of pleural effusion as bio-source for diagnostic biomarker tests 227 6 Molecular diagnostics performed in clinical practice Time of sampling Clinical application Assay Results Tumor cell percentage (estimated by pathologist on Giemsa slide) very low very low unknown no tumor no tumor molecular profiling not possible no tumor no tumor molecular profiling not possible no tumor no tumor Cell pellet Original driver copies /µl WT original driver copies /µl EGFR T790M copies /µl WT EGFR T790M copies /µl 22 1530 4 1613 300 8820 3778 11780 94 565 341 4500 259 4670 955 1160 325 13450 41 22 7265 12150 165 4755 0 5035 865 5765 429 6045 210 22500 0 21840 483 1690 0 1950 7987 4195 0 11725
RkJQdWJsaXNoZXIy MTk4NDMw