Chapter 2 60 Figure S3. Association of PD-L1 TPS with DC at 6 months and impact of tissue sample properties on the predictive accuracy of PD-L1. (A) Percentage of patients with ≥50% (n=8), 1-50% (n=19) and 0% PD-L1 expression (n=50) in pretreatment samples showing DC 6m and PD in the validation set (n=77). (B) ROC curve for predictive value of PD-L1 for DC 6m (AUC 0.58; 95%-CI 0.43-0.74) in the validation set (n=77). (C-D) The predictive value of PD-L1 TPS in the total cohort and different subgroups. Each comparison is marked in a grey square. Shown is the area under the curve (AUC) for DC 6m (C) and 12m (D) with 95% CI interval. The dashed line indicates the AUC of PD-1T TILs in the total cohort. P-value was determined by one-sided permutation test.
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