101 Host response in patients with ICU-acquired pneumonia STROBE statement Item Recommendation Page Title and abstract 1 (a) Indicate the study’s design with a commonly used term in the title or the abstract 1 (b) Provide in the abstract an informative and balanced summary of what was done and what was found 1 Introduction Background/ rationale 2 Explain the scientific background and rationale for the investigation being reported 3 Objectives 3 State specific objectives, including any prespecified hypotheses 3 Methods Study design 4 Present key elements of study design early in the paper 4 Setting 5 Describe the setting, locations, and relevant dates, including periods of recruitment, exposure, follow-up, and data collection 4 Participants 6 (a) Give the eligibility criteria, and the sources and methods of selection of participants. Describe methods of follow-up 4 (b) For matched studies, give matching criteria and number of exposed and unexposed NA Variables 7 Clearly define all outcomes, exposures, predictors, potential confounders, and effect modifiers. Give diagnostic criteria, if applicable 4-5, Additional File 1: 7-9 Data sources/ measurement 8 For each variable of interest, give sources of data and details of methods of assessment (measurement). Describe comparability of assessment methods if there is more than one group 5-6, Additional File 1: 9-11 Bias 9 Describe any efforts to address potential sources of bias 5 Study size 10 Explain how the study size was arrived at 4 Quantitative variables 11 Explain how quantitative variables were handled in the analyses. If applicable, describe which groupings were chosen and why 4-5, Additional File 1: 10-11 5
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