106 Chapter 5 Leukemia Diagnosis or prior diagnosis of either acute myeloid leukemia, chronic myeloid leukemia, acute lymphocytic leukemia, chronic lymphocytic leukemia, and polycythemia vera. Lymphoma Diagnosis or prior diagnosis of either Hodgkin’s disease, lymphosarcoma, Waldenstrom macroglobulinemia, myeloma, and other lymphomas. Solid tumor without metastasis Solid tumors without documented metastases, but initially treated in the last 5 years. Solid tumor with metastasis Solid tumor with metastases. Acquired Immune Deficiency Syndrome (AIDS) Definite or probable AIDS (i.e., AIDS related complex). AIDS is defined as a HIV+ status with a CD4 cell count <200 cells/microLiter or the presence of any AIDS-defining condition regardless of the CD4 cell count. AIDS-defining conditions are opportunistic illnesses that occur more frequently or more severely because of immunosuppression. These include mainly opportunistic infections, but also certain malignancies as well as conditions without clear alternative etiology thought to be related to uncontrolled HIV infection itself, such as wasting or encephalopathy. Immunosuppression The subject has received therapy that suppresses resistance to infection e.g. immunosuppressants, chemotherapy, radiation, long term or recent high dose steroids*, or has a disease that is sufficiently advanced to suppress. *The following is considered high dose of corticosteroids: If a subject uses one or more of the following medications daily for≥14 days intravenous or oral (so don’t include ‘every other day’ or topical use): prednisone ≥ 20mg (Lodotra, DiAdreson-F), methylprednisolone≥16mg (Depo-Medrol/SoluMedrol), cortisone≥100mg, hydrocortisone≥80mg (Solu-Cortef), dexamethasone≥3,2mg (Oradexon), betamethasone≥3,2mg (Celestone), triamcinolone(acetamide) ≥16mg (Kenacort-A). Adapted from [1].
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