111 Host response in patients with ICU-acquired pneumonia APACHE IV Acute Physiology and Chronic Health Evaluation IV; ICU intensive care unit; IQR interquartile range. A control was defined as a subject who did not develop a protocol defined ICU-acquired pneumonia. From all controls (n=1681) we randomly selected a subset in a 2:1 ratio to the cases using the sample function without replacement of the R statistical framework. Continuous nonparametric data were analyzed using a Wilcoxon signed rank sum- or KruskalWallis test; categorical data were analyzed using a Fisher exact test; continuous parametric data were analyzed using a Student t test; a P value < 0.05 was considered statistically significant. Table S2. Missing clinical data Cases (n = 277) Controls (n = 632) Baseline data Age 0 0 Female sex 0 0 Body Mass Index 4 (1.4) 7 (1.1) Charlson Comorbidity Index 0 1 (0.2) Origin prior to ICU admission 11 (4.0) 17 (2.7) Primary reason for ICU admission 0 0 Colonized with Staphylococcus aureus on admission 0 0 Pneumonia on ICU admission 0 0 APACHE IV score 0 0 Laboratory values at ICU admission White blood cells 1 (0.4) 6 (0.9) Neutrophils 118 (42.6) 220 (34.8) Monocytes 129 (46.6) 232 (36.7) Lymphocytes 114 (41.2) 217 (34.3) Platelets 2 (0.7) 6 (0.9) Outcome data Length of ICU stay 0 0 Readmission <30 days of ICU discharge 0 0 Status at Day 90 after ICU admission 21 (7.6) 56 (8.9) APACHE IV Acute Physiology and Chronic Health Evaluation IV; ICU intensive care unit; IQR interquartile range. Variables are displayed as count (percentage). 5
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