113 Host response in patients with ICU-acquired pneumonia Table S4. Overview of linear mixed model estimates comparing cases with controls at baseline and onset of Intensive Care Unit-acquired pneumonia Baseline Group difference Event Group difference Interaction coef ficient (95%CI) P value (BH) coef ficient (95%CI) P value (BH) P value Cytokine release and systemic inflammation IL-6 unadjusted 48.0% (22.6―78.6) <0.0001 49.7% (59.4―37.7) <0.0001 0.0109 adjusted 46.3% (21.3―76.5) 0.0014 49.1% (58.9―37) <0.0001 0.0110 IL-8 unadjusted 12.5% (-1.6―28.5) 0.1229 19.4% (30.7―6.2) 0.0090 0.2169 adjusted 10.6% (-3.1―26.2) 0.2024 17.6% (29.1―4.3) 0.0183 0.2364 IL10 unadjusted 10.3% (-1.5―23.6) 0.1229 9.0% (20.2―3.7) 0.1842 0.9615 adjusted 9.0% (-2.8―22.2) 0.2024 8.0% (19.3―4.8) 0.2472 0.9739 IL-1RA unadjusted 26.6% (7.1―49.7) 0.0220 26.5% (39.3―11) 0.0033 0.4960 adjusted 24.9% (6.0―47.3) 0.0306 25.7% (38.4―10.4) 0.0047 0.4803 Procalcitonin unadjusted 50.2% (18―91.3) 0.0062 53.1% (64.2―38.5) <0.0001 0.0099 adjusted 46.3% (15.9―84.6) 0.0087 51.4% (62.6―36.9) <0.0001 0.0112 MMP-8 unadjusted 48.1% (20.7―81.8) 0.0017 43.2% (55.2―28.1) <0.0001 0.1596 adjusted 45.2% (18.4―78.2) 0.0034 41.6% (53.9―26.1) <0.0001 0.1806 sTREM-1 unadjusted 12.5% (2.2―23.8) 0.0351 15.9% (24.3―6.7) 0.0027 0.1827 adjusted 9.7% (0.5―19.7) 0.0935 13.5% (21.4―4.8) 0.0066 0.2050 sRAGE unadjusted 17.1% (6.3―29) 0.0069 25.5% (33.1―17) <0.0001 0.0059 adjusted 15% (4.8―26.3) 0.0158 24.2% (31.6―15.9) <0.0001 0.0057 Tenascin-C unadjusted 3.8% (-3―11.1) 0.2954 11.4% (17.8―4.4) 0.0033 0.0177 adjusted 2.4% (-4.2―9.5) 0.5043 10.2% (16.6―3.3) 0.0087 0.0174 Endothelial cell and procoagulant response sCD163 unadjusted 8.3% (-6.1―25) 0.2954 8.4% (21.6―7.0) 0.2671 0.9030 adjusted 5.4% (-8.2―21.1) 0.5043 5.4% (18.7―10.0) 0.4695 0.9597 sE-selectin unadjusted 6.8% (-3.4―18) 0.2383 13.5% (22.5―3.4) 0.0148 0.0992 adjusted 6.1% (-3.9―17.1) 0.2846 13.1% (22―3.1) 0.0183 0.0925 sVCAM-1 unadjusted 15.7% (-0.5―34.4) 0.0997 26.1% (37.5―12.7) 0.0012 0.0456 adjusted 11.8% (-3.5―29.4) 0.2024 23% (34.6―9.4) 0.0046 0.0544 Fractalkine unadjusted 6.5% (1.3―12) 0.0334 9.6% (14.6―4.3) 0.0014 0.1874 adjusted 5.8% (0.6―11.2) 0.0750 9% (14―3.7) 0.0036 0.1886 s-Thrombomodulin unadjusted 8.0% (-0.1―16.8) 0.0996 9.8% (17―1.9) 0.0221 0.4162 adjusted 5.3% (-2.1―13.2) 0.2265 7.4% (14.4―0.2) 0.0757 0.4163 Syndecan-1 unadjusted 8.3% (-2.7―20.6) 0.1830 6.7% (17.1―5.1) 0.2671 0.8356 5
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