115 Host response in patients with ICU-acquired pneumonia Table S5. Patient characteristics and clinical outcome of cases in whom pneumonia occurred prior to day 7 (i.e., in whom a baseline, event and post-pneumonia sample was obtained) Overall (n = 122) Baseline data Age, yr, mean (SD) 62.3 (16.1) Female sex, n (%) 90 (73.8) Body Mass Index, mean (SD) 26.7 (5.1) Charlson Comorbidity Index, median (IQR) 3.0 [2.0, 5.0] Origin prior to ICU admission, n (%) Home 33 (27.0) General ward 66 (54.1) Long term facility 19 (15.6) Other ICU 4 (3.3) Primary reason for ICU admission, n (%) Medical 51 (41.8) Surgical, cardiothoracic 5 (4.1) Surgical, other 38 (31.1) Trauma 28 (23.0) Colonized with Staphylococcus aureus on admission, n (%) 63 (51.6) Pneumonia on ICU admission, n (%) 17 (13.9) APACHE IV, mean (SD) 70.7 (38.1) Laboratory values at ICU admission White blood cells, 109/L, median (IQR) 13.3 [9.4, 19.5] Neutrophils, 109/L, median (IQR) 10.7 [7.1, 14.8] Monocytes, 109/L, median (IQR) 0.7 [0.5, 1.0] Lymphocytes, 109/L, median (IQR) 0.9 [0.5, 1.2] Platelets, 109/L, median (IQR) 201.5 [151.5, 257.2] Outcome data Length of ICU stay (median [IQR]) 14.5 [11.0, 23.8] Readmission <30 days of ICU discharge, n (%) 8 (6.6) 90-day mortality after ICU admission, n (%) 45 (39.8) APACHE IV Acute Physiology and Chronic Health Evaluation IV; ICU intensive care unit; IQR interquartile range. Continuous nonparametric data were analyzed using a Wilcoxon signed rank sum- or Kruskal-Wallis test; categorical data were analyzed using a Fisher exact test; continuous parametric data were analyzed using a Student t test. 5
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