119 Host response in patients with ICU-acquired pneumonia Figure S1. Schematic representation of the clinical course of 277 cases during Intensive Care Unit-stay. Each bar represents a case with its individual length of Intensive Care Unit (ICU)-stay and colours indicate sampling timepoints. Blood was obtained upon enrolment into ASPIRE-ICU (baseline), on the day the pneumonia was diagnosed (event), and on day 7 after study inclusion. There was no event-sample available for analysis in 29 cases. In 16 cases the sample drawn on day 7 after inclusion was taken on the same day as pneumonia was diagnosed. In 135 cases (54.9%) the event was prior to the standard follow-up sample taken 7 days after enrolment into the study; of these, from 122 were 3 sequential samples (baseline, event, post-event) available for biomarker analyses. Definition of abbreviations: ICU = intensive care unit. 5
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