123 Host response in patients with ICU-acquired pneumonia ** 101.4 101.6 101.8 102 Baselin e Event Post−Event IL−6 (pg/mL) IL−6 101.3 101.4 101.5 Baselin e Event Post−Event IL−8 (pg/mL) IL−8 103.3 103.4 103.5 103.6 Baselin e Event Post−Event IL−1RA (pg/mL) IL−1RA *** 105.8 105.9 106 106.1 106.2 Baselin e Event Post−Event sCD163 (pg/mL) sCD163 *** 103.3 103.4 103.5 103.6 Baselin e Event Post−Event sRAGE (pg/mL) sRAGE ** 104.1 104.15 104.2 104.25 104.3 104.35 104.4 Baselin e Event Post−Event Tenascin−C (pg/mL) Tenascin−C * ** 102.6 102.8 103 103.2 Baselin e Event Post−Event Procalcitonin (pg/mL) Procalcitonin Cases 100.9 101 101.1 101.2 Baselin e Event Post −Event IL−10 (pg/mL) IL−10 103.7 103.8 103.9 104 104.1 Baselin e Event Post−Event MMP−8 (pg/mL) MMP−8 102.4 102.45 102.5 102.55 102.6 102.65 102.7 Baselin e Even t Post−Event sTREM−1 (pg/mL) sTREM−1 Figure S5. Cytokine and systemic inflammatory responses in patients in whom pneumonia occurred prior to day 7 (i.e., in whom a baseline, event and post-pneumonia sample was obtained) Only cases were included with paired data (baseline plus event) who also had a post-event measurement (n = 122 patients). Asterisks indicate differences between timepoints (*P <0.05, **P <0.01, ***P <0.001). Definition of abbreviations: CD = cluster of differentiation; IL = interleukin; MMP = matrix metalloproteinase; RA = receptor antagonist; RAGE = receptor for advanced glycation endproducts; s = soluble; TREM = triggering receptor expressed on myeloid cells. 5
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