126 Chapter 5 p1 = 0.0061 p2 = 0.0019 104.4 104.6 104.8 105 105.2 2 5 10 20 30 Time to ICU-A Pneumonia sE-Selectin (pg/mL) Baseline sE-Selectin p1 = 0.1347 p2 = 0.8978 106.4 106.6 106.8 107 2 5 10 20 30 Time to ICU-A Pneumonia sVCAM-1 (pg/mL) Baseline sVCAM-1 p1 = 0.0269 p2 = 0.0323 103.8 103.9 104 104.1 2 5 10 20 30 Time to ICU-A Pneumonia Fractalkine (pg/mL) Baseline Fractalkine p1 = 0.0149 p2 = 0.4551 103.8 103.9 104 104.1 2 5 10 20 30 Time to ICU-A Pneumonia sThrombomodulin (pg/mL) Baseline sThrombomodulin p1 = 0.0421 p2 = 0.5269 103.8 104 104.2 104.4 2 5 10 20 30 Time to ICU-A Pneumonia Syndecan-1 (pg/mL) Baseline Syndecan-1 p1 = 0.078 p2 = 0.0659 103 103.2 103.4 103.6 103.8 2 5 10 20 30 Time to ICU-A Pneumonia Angiopoietin-1 (pg/mL) Baseline Ang-1 p1 = 0.0109 p2 = 0.0184 103.6 103.8 104 104.2 104.4 2 5 10 20 30 Time to ICU-A Pneumonia Angiopoietin-2 (pg/mL) Baseline Ang-2 p1 = 0.0656 p2 = 0.1812 101.7 101.8 101.9 102 2 5 10 20 30 Time to ICU-A Pneumonia sTissue factor (pg/mL) Baseline sTissue factor p1 = 0.3087 p2 = 0.8416 106.6 106.7 106.8 106.9 107 2 5 10 20 30 Time to ICU-A Pneumonia D-Dimer (pg/mL) Baseline D-Dimer Figure S8. Baseline endothelial cell and procoagulant responses in Intensive Care Unit (ICU) patients who developed ICU-acquired pneumonia. Baseline value plotted against the time of onset of the event in the ICU with 95% confidence intervals. Adjusted regression analysis for the following clinical baseline characteristics: site of enrolment, age, gender, body mass index, Charlson comorbidity index, reason for admission (medical, surgery, trauma), S. aureus colonization status, Acute Physiology And Chronic Health Evaluation (APACHE)-IV score, and immunosuppressed status. P value <0.05 of p1 indicates that the time of onset of pneumonia was significantly associated with the biomarker level at ICU admission. P value of p2 indicates nonlinearity (P <0.05) of the association of p1, assessed with the Wald statistic using restricted cubic splines. Definition of abbreviations: ICU-A = Intensive Care Unit acquired; s = soluble; VCAM = vascular cell adhesion protein.
RkJQdWJsaXNoZXIy MTk4NDMw