144 Chapter 6 interventions where targeted therapy aims to optimize the balance between efficacy and toxicity, emphasis on targeted antimicrobial therapy principles in patients with sepsis should be considered in the same fashion. Acknowledgements The authors would like to acknowledge the Christina Chantell and Elizabeth Wood for their expertise and guidance in the evaluation of this review. Funding W.J.W. received a Vidi grant (91716475) from the Netherlands Organisation for Scientific Research (NWO). H.S.V. and W.J. W received a Marie Curie Skledowska Innovative Training Network (MCITN) European Sepsis Academy, funded by the European Union’s Horizon 2020 programme. Transparency declarations A.A.B. is currently an employee of the Scientific Affairs group of Accelerate Diagnostics, Inc. T.S.R.v.E., H.S.V. and W.J.W. declare no competing interests.
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