161 Microbiome modulation by antibiotics in patients with asthma Supplementary Table 1. Clinical and demographic characteristics of patients with asthma and HDM allergy enrolled in the study control n = 13 antibiotic treatment n = 7 General Female (%) 10 (76.9) 6 (85.7) Age, years (mean (SD)) 22.5 (2.2) 24.3 (2.5) BMI (mean (SD) 23.7 (3.1) 23.2 (3.3) Asthma related symptoms (%) Wheezing 4 (30.8) 0 (0.0) Cough 4 (30.8) 0 (0.0) Dyspnea 2 (15.4) 1 (14.3) Chest tightness 6 (46.2) 4 (57.1) Seasonal variability 4 (30.8) 4 (57.1) Symptom progression at night 8 (61.5) 5 (71.4) Eczema 6 (46.2) 5 (71.4) Allergic rhinitis 3 (23.1) 1 (14.3) Family history of atopy 5 (38.5) 3 (42.9) Allergy Positive skin prick test House dust mite (%) 13 (100.0) 7 (100.0) Total IgE (kU/L) (median [IQR]) 351.00 [278.00, 506.00] 266.00 [99.05, 334.50] D. pteronyssinus IgE (kU/L) (median [IQR]) 32.40 [24.20, 84.70] 12.80 [5.98, 46.85] Lung spirometry FVC L (median [IQR]) 4.32 [3.79, 4.68] 4.58 [4.10, 4.93] FVC % of predicted (median [IQR]) 109.00 [94.00, 112.00] 108.00 [97.50, 117.50] FEV1 L (median [IQR]) 3.28 [3.10, 4.06] 3.71 [3.57, 4.00] FEV1 % of predicted (median [IQR]) 96.00 [88.00, 106.00] 105.00 [95.00, 113.00] Methacholine PC20 (mg/mL) (median [IQR]) 2.71 [1.79, 4.90] 2.08 [1.71, 2.98] Data are presented as numbers (percentages) for categorical variables, median and interquartile ranges (IQR, Q1-Q3) for nonparametric quantitative variables, and mean ± standard deviation of the mean (SD) for parametric quantitative variables. Forced expiratory volume in 1 second (FEV1); Forced vital capacity (FVC); Immunoglobulin E (IgE); Kilo units per liter (kU/L); PC20, defined as concentration methacholine bromide required to achieve 20% fall in FEV1. 7
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