180 Chapter 8 Declarations Ethics approval and consent to participate The study protocol was approved by the ethics review board of the Academic Medical Center (AMC) at the University of Amsterdam (Amsterdam, the Netherlands). The OPTIMACT trial was registered in Netherlands National Trial Register under number NTR6163. Written informed consent was obtained from all subjects (patients) in this study. Consent for publication Not applicable. Availability of data and materials The datasets used and/or analysed during the current study are available from the corresponding author on reasonable request. Competing interests The authors of this manuscript declare no relationships with any companies, whose products or services may be related to the subject matter of the article. Funding The OPTIMACT study was funded by an innovation grant of the Amsterdam UMC, University of Amsterdam and a Health Care Efficiency Program grant of the Netherlands Organisation for Health Research and Development (ZonMW: 843001806). Neither organization had influence on the design of the study, collection of data, data analysis, interpretation of data, or writing of the manuscript. Authors’ contributions TvE, PB and JP designed the study. MK, IvdB, MB and JS contributed to the study design. TvE, MK, MB, HS and SH acquired the data. TvE and SH analysed the data. TvE, JP and PB interpreted the data. TvE drafted the manuscript under supervision of JP. All authors read, critically revised and approved the final manuscript. Acknowledgements The authors gratefully acknowledge Erwin Hoolwerf, Koen van der Ploeg, Merve Tulek and Nina-Suzanne Groeneveld (medical students, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands), Fien van Beveren (medical student, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands), Sietske Okkema (medical student, Leiden University, the Netherlands) for their participation in this study, and Hessel Peters-Sengers (Center of Experimental and Molecular Medicine, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands) for statistical advice and assistance.
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