263 Towards precision medicine in sepsis Resistance genes or antibioticsd Sensitivity (%) Specificity (%) Cost Instrument Test - 75e 92f 88e 81f €€€ € - 88-100 97-100 € €€ mecA 98-99 99-100 €€ €€ mecA 94-99 96-98 €€ €€ mecA, vanA, vanB 96-99 98-100 € €€ mecA, vanA/B, blaKPC 80-97 91-100 €€ €€€ mecA, vanA, vanB 93-100 94-100 €€ €€€ blaCTX-M, blaKPC, blaNDM, blaVIM, blaIMP, blaOXA-48 blaOXA-23, blaOXA-24/40, blaOXA-58 89-100 93-100 €€ €€€ mecA, vanA/B, blaCTX-M, blaSHV, blaKPC, blaNDM, blaIMP, blaOXA-48, blaOXA-23, blaOXA-24/40, blaOXA-51, blaOXA-58 93 100 € €€€ CFT, DAP, ERY, LZD, VAN (S. aureus); DAP, VAN (CoNS); AMP, DAP, LZD (Enterococcus spp.); AMK, ATM, CAZ, CIP, CRO, ERT, FEP, GE, MEM, SAM, TOB, TZP (E. coli; Klebsiella spp.; Proteus spp.), AMK, ATM, CAZ, CIP, CRO, ERT, FEP, GE, MEM, SAM, TOB, TZP (Enterobacter spp., Citrobacter spp;, Serratia spp.), AMK, CAZ, CIP, FEP, GE, MEM, TOB, TZP (P. aeruginosa); AMK, TZP (A. baumannii) 89-96 (ID) 91-95 (AST)g 99-100 (ID) €€ €€€ cefepime; GEN, gentamicin; LZD, linezolid; MEM, meropenem; SAM, ampicillin-sulbactam; TOB, tobramycin; TZP, piperacillin-tazobactam; VAN, vancomycin. e Overall sensitivity and specificity values for identifications at the species level. f Overall sensitivity and specificity values for identifications at the genus level. g Overall categorical agreement. 11
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