51 Biomarkers in sepsis No of subjects and/or validation cohort Results Reference Validation in five cohorts from two ICUs in the Netherlands (n=308) AUC 0.89 McHugh et al., 2015 15 cohorts (4 cohorts time-matched infected versus noninfected trauma patients; 3 cohorts ICU/trauma patients with infections; 8 cohorts healthy subject versus sepsis patients AUC 0.87 Sweeney et al., 2015 Internal validation that divided subjects into six phenotypes (n=72); external validation in German cohort (n=196) and Greek cohort (n=50) AUC 0.81 Bauer et al., 2016 Validation in two tertiary ICUs in the Netherlands (n=100) AUC 0.85 Scicluna et al., 2015 No of subjects and/or validation cohort Results Reference Five external validation cohorts (n=328) AUC 0.87 Tsalik et al., 2016 Cases and controls were random divided into a stratified training set and validation test set Sensitivity 0.95, specificity 0.92 Suarez et al., 2015 Two independent datasets: USA (n=131) and Spain (n=19) Mean percentage of correct classification 83% Parnell et al., 2012 30 independent cohorts AUC 0.91 Sweeney et al., 2016 3
RkJQdWJsaXNoZXIy MTk4NDMw