69 Hyperferritinemia in patients with pneumonia Cytokines 10 100 1,000 10,000 IL−6 (pg/mL) IL−6 ** 10 100 IL−8 (pg/mL) IL−8 *** 0 1 10 100 1,000 IL−10 (pg/mL) IL−10 10 100 1,000 IL−23 (pg/mL) IL−23 * 1 IL−27 (ng/mL) IL−27 * 1 10 100 IL−1RA (ng/mL) IL−1RA Median control subjects Group Ferritin <500 ng/ml Ferritin ≥500 ng/ml Figure 3. Plasma cytokine levels in patients with CAP stratified according to a plasma ferritin concentration of <500 ng/ml or ≥500 ng/ml. Patients were stratified into those with plasma ferritin <500 ng/ml (n = 128) or ≥500 ng/ml (n = 46). Data are expressed as box-and-whisker diagrams with the horizontal line depicting the median, the top and bottom of the box representing the lower and upper quartiles, and whiskers extending to the farthest points that are not outliers (i.e., that are within 1.5 times the interquartile range of the lowest and the highest quartile, respectively). Dotted lines represent median values obtained in 50 age- and sex matched controls. Asterisks indicate differences between groups (Benjamini-Hochberg corrected, *p <0.05, **p <0.01, ***p <0.001). IL = interleukin; RA = receptor antagonist. 4
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