Tjitske van Engelen

76 Chapter 4 Supporting information Supplementary Table 1. Causative pathogens of patients with CAP stratified according to a plasma ferritin concentration of <500 ng/ml or ≥500 ng/ml Low ferritin (<500ng /ml) Elevated ferritin (≥500ng /ml) P value Patients, n 128 46 Pathogen found 67 (52.3) 25 (54.3) 0.951 Bacteria 36 (28.1) 16 (34.8) 0.510 Streptococcus pneumoniae 15 (11.7) 7 (15.2) 0.724 Heamophilus influenzae 9 (7.0) 3 (6.5) >0.99 Staphylococcus aureus 3 (2.3) 1 (2.2) >0.99 Pseudomonas aeruginosa 3 (2.3) 0 (0.0) 0.699 Pneumocystis carinii 0 (0.0) 2 (4.3) 0.117 Escherichia coli 1 (0.8) 0 (0.0) >0.99 Klebsiella pneumoniae 0 (0.0) 1 (2.2) 0.592 Legionella pneumophila 0 (0.0) 1 (2.2) 0.592 Mycobacterium tuberculosis 0 (0.0) 1 (2.2) 0.592 Other bacterium1 7 (5.5) 1 (2.2) 0.614 Viruses 17 (13.3) 12 (26.1) 0.077 Influenza A virus 10 (7.8) 2 (4.3) 0.648 Influenza B virus 4 (3.1) 3 (6.5) 0.570 Rhinovirus 4 (3.1) 0 (0.0) 0.523 Coronavirus (not SARS-Cov-2) 3 (2.3) 1 (2.2) >0.99 Respiratory syncytial virus 2 (1.6) 0 (0.0) 0.963 Parainfluenza 1-4 1 (0.8) 1 (2.2) >0.99 Other virus2 1 (0.8) 0 (0.0) >0.99 1In ELDERBIOME: Rothia dentocariosa (n = 1), Stenotrophomonas maltophilia (n = 1), Streptococcus pyogenes (n = 1), Mycoplasma pneumoniae (n = 1); for OPTIMACT not further specified. 2Not present in ELDERBIOME; for OPTIMACT not further specified.

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