78 Chapter 4 1 Congestive heart failure, myocardial infarction, peripheral vascular disease; 2 Cerebrovascular disease, dementia; 3 Immune deficiency (such as human immune deficiency virus (HIV) infection, acquired immune deficiency syndrome (AIDS), asplenia), use of immune suppressive drugs (such as corticosteroids, antineoplastic medication, methotrexate). COPD: Chronic Obstructive Pulmonary Disease; PSI: Pneumonia Severity Index; MEWS: Modified Early Warning Score; qSOFA: quick Sequential Organ Failure Assessment score; bpm: breaths/beats per minute; mmHg: millimeter of mercury. * Kruskal-Wallis test probability † Chi-square test probability ‡ Student t-test Systemic inflammation and neutrophil response ** 0 10 100 1,000 10,000 CRP (mg/L) CRP 0.1 1 sTREM−1 (ng/mL) sTREM−1 * 0.1 1 10 CD163 (µg/mL) sCD163 ** 10 50 Tenascin−C (ng/mL) Tenascin−C ** 10 100 MPO (ng/mL) MPO 10 100 Proteinase−3 (ng/mL) Proteinase−3 0 100 1,000 NGAL (ng/mL) NGAL Median control subjects Group Ferritin <250 ng/ml Ferritin ≥250 ng/ml Supplementary Figure 1. Systemic inflammatory and neutrophil responses of patients with CAP stratified according to a plasma ferritin concentration of <250 ng/ml or ≥250 ng/ml. Patients were stratified into those with plasma ferritin <250 ng/ml (n = 84) or ≥250 ng/ml (n = 90). Data are expressed as box-and-whisker diagrams with the horizontal line depicting the median, the top and bottom of the box representing the lower and upper quartiles, and whiskers extending to the farthest points that are not outliers (i.e., that are within 1.5 times the interquartile range of the lowest and the highest quartile, respectively). Dotted lines represent median values obtained in 50 age- and sex matched subjects. Asterisks indicate differences between groups (Benjamini-Hochberg corrected, *p <0.05, **p <0.01). CRP = C-reactive protein; sTREM = soluble triggering receptor expressed on myeloid cells; sCD = soluble cluster of differentiation; MPO= myeloperoxidase; NGAL = neutrophil gelatinase-associated lipocalin.
RkJQdWJsaXNoZXIy MTk4NDMw