90 Chapter 5 Controls Cytokine release and systemic inflammatory responses Endothelial cell and procoagulant responses *** *** Interaction* * *** 101.4 101.6 101.8 Baseline Event IL−6 (pg/mL) IL−6 ** 101.3 101.4 101.5 101.6 Baseline Event IL−8 (pg/mL) IL−8 * * 100.9 100.95 101 101.05 101.1 101.15 Baseline Event IL−10 (pg/mL) IL−10 * ** * 103.3 103.4 103.5 103.6 Baseline Event IL−1RA (pg/mL) IL−1RA ** *** Interaction* *** *** 102.4 102.6 102.8 103 103.2 Baseline Event Procalcitonin (pg/mL) Procalcitonin * ** 102.45 102.5 102.55 102.6 102.65 Baseline Event sTREM−1 (pg/mL) sTREM−1 103.2 103.3 103.4 103.5 103.6 Baseline Event sRAGE (pg/mL) sRAGE *** *** 103.6 103.7 103.8 103.9 104 104.1 Baseline Event MMP−8 (pg/mL) MMP−8 *** *** 105.8 105.9 106 106.1 Baseline Event sCD163 (pg/mL) sCD163 ** Interaction* ** 104.15 104.2 104.25 104.3 Baseline Event Tenascin−C (pg/mL) Tenascin−C ** *** Interaction** * *** * 104.45 104.5 104.55 104.6 Baseline Event sE−selectin (pg/mL) sE−selectin ** Interaction* * 106.4 106.5 106.6 106.7 Baseline Event sVCAM−1 (pg/mL) sVCAM−1 * ** * 103.8 103.85 103.9 Baseline Event Fractalkine (pg/mL) Fractalkine * 103.8 103.85 103.9 103.95 Baseline Event sThrombomodulin (pg/mL) sThrombomodulin *** *** 103.8 103.9 104 104.1 Syndecan−1 (pg/mL) Syndecan−1 Baseline Event *** *** 103.5 103.6 103.7 Baseline Event Angiopoietin−1 (pg/mL) Angiopoietin−1 * *** Interaction*** *** 103.5 103.6 103.7 103.8 103.9 Baseline Event Angiopoietin−2 (pg/mL) Angiopoietin−2 * ** 101.65 101.7 101.75 101.8 Baseline Event sTissue factor (pg/mL) sTissue factor *** *** 106.7 106.75 106.8 106.85 106.9 Baseline Event D−dimer (pg/mL) D−dimer Cases Figure 2. Plasma protein biomarkers indicative of cytokine release and systemic inflammatory responses, and endothelial cell and procoagulant responses, in Intensive Care Unit (ICU) patients stratified according to the development of an ICU-acquired pneumonia (case) or not (control) at baseline, event, and their change over time. The baseline sample was obtained upon enrolment
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