101 Blood biomarkers during and after treatment Secondary objectives were to evaluate whether there was an association between HS-TNT and NT-ProBNP levels at different time points (including the course of these biomarkers) and dose to organs at risk (OARs). Furthermore, we evaluated the association of these biomarkers with clinical events, and the association between radiation dose and clinical events (figure 1) . Figure 1: A. Timeline trial and B. Intended analyses. Analyses at the different time points were performed using logistic or linear regression analyses for binary and continuous endpoints, respectively. Longitudinal analyses analysing associations between subjects within the groups were performed using MANOVA (multivariate analyses of variance) for repeated binary measurements, whereas generalized estimating equation analyses (GEE) were used for the continuous parameters. To compensate for potential confounders, we included other clinical factors reported in literature in the multivariable analysis. 7
RkJQdWJsaXNoZXIy MTk4NDMw