105 Blood biomarkers during and after treatment Table 2 Course of lab values(a) and lab values at separate moments (b,c) versus radiation dose A. HS-TNT course (longitudinal GEE analysis) Univariate analyses HS-TNT Multivariate analyses HS-TNT DVH parameters Regr.coefficient (β) ; p value DVH parameters( β; p value) Cardiac history( β; p value) V5 heart 0.05; p=0.04 0.07; p<0.01 8.40; p<0.01 V20 heart NS 0.09; p=0.01 8.57; p<0.01 V25 heart 0.12; p=0.02 0.14; p<0.01 8.37; p<0.01 V30 heart 0.18; p=0.03 0.20; p<0.01 8.31; p<0.01 V35 heart NS NS 8.35; p<0.01 V40 heart NS NS 8.10; p<0.01 MHD 0.25; p=0.02 0.31; p<0.01 8.49; p<0.01 V5 Lung NS V20 Lung NS MLD NS Cardiac event history 8.1; p<0.01 Any new cardiac event NS B. HS-TNT at different time moments versus radiation dose parameters H S - T N T absolute values V5 Lung V20 Lung MLD V25 Heart V30 Heart V35 heart V40 Heart MHD Baseline NS NS NS NS NS NS NS NS e n d o f treatment NS NS NS 0.17; p=0.01 0.23; p=0.01 NS 0.46; p=0.01 0.34; p=0.02 4 weeks NS NS NS NS NS NS NS NS 6 months NS NS NS NS NS NS NS NS 7
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