106 Chapter 7 1 year NS NS NS NS 0.48; p=0.02 NS NS NS 2 years NS NS NS NS 0.56; p=0.05 NS NS NS HS-TNT(% to baseline) V5 Lung V20 Lung MLD V25 Heart V30 Heart V35 heart V40 Heart MHD e n d o f treatment NS NS NS NS NS 2.49; p=0.03 NS NS 4 weeks NS NS NS NS NS NS NS NS 6 months NS NS NS NS NS NS NS NS 1 year NS NS NS NS NS NS NS NS 2 years NS NS NS NS NS NS NS NS Correlation coefficients and Significance levels of (the rise) of HS-TNT vs radiation dose parameters C. NT-ProBNP(% baseline) V5 lung V20 lung MLD V25 Heart V30 Heart V35 Heart V40 Heart MHD e n d o f treatment* 4.56; p<0.01 15.06; p<0.01 30.93; p<0.01 NS 3.77; p=0.04 5.45; p=0.04 10.44; p<0.01 * NS 4 weeks** NS NS NS NS NS NS NS -8.20; p=0.05 6 months NS NS NS NS NS NS NS NS 1 year NS NS NS NS NS NS NS NS 2 years NS NS NS NS NS NS NS NS Correlation coeficients and significance levels of the rise of NT proBNP vs radiation dose parameters * when combining MLD with heart V30, V35 or V40, the heart parameters lose significance ** negative dose response in the mean heart dose (correspondingto the low dose range V values)was not considerd relevant because of low number of patients with these low V values and when correcting for e.g. cervical tumours with low, low dose range heart values it loses significance. results did not change when excluding the outlier of absolute values case number 5
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