108 Chapter 7 Figures 2 MANOVA analyses on biomarkers vs toxicty endpoints In the MANOVA analysis, patients that died from cardiopulmonary or unknown causes (n=11), as a surrogate for grade 5 toxicity, showed a significantly different rise of both HS-TNT (p=0.03) as well as NT-proBNP (p=0.01), as compared to patient who did not die or died of other known causes. Regarding HS-TNT, this difference was predominantly seen in the first 4 weeks after treatment (time frame 2), while for NT-ProBNP this difference was seen in time frame 1 (p<0.01, during treatment) and timeframe 3 (p<0.01, 4 weeks-6 months after treatment). As five of these 11 patients died within 6 months after treatment, the number patients left is too small to draw firm conclusions (more details in supplementary 4).
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