129 Summarized discussion and future perspectives. References [1] Beukema JC, Van Luijk P, Widder J, Langendijk JA, Muijs CT. Is cardiac toxicity a relevant issue in the radiation treatment of esophageal cancer? Radiother Oncol 2015;114:85–90. https://doi. org/10.1016/j.radonc.2014.11.037. [2] Beukema JC, Kawaguchi Y, Sijtsema NM, Zhai TT, Langendijk JA, van Dijk L V., et al. Can we safely reduce the radiation dose to the heart while compromising the dose to the lungs in oesophageal cancer patients? Radiother Oncol 2020;149:222–7. https://doi.org/10.1016/j.radonc.2020.05.033. [3] de Groot C, Beukema JC, Langendijk JA, van der Laan HP, van Luijk P, van Melle JP, et al. RadiationInduced Myocardial Fibrosis in Long-Term Esophageal Cancer Survivors. Int J Radiat Oncol Biol Phys 2021. https://doi.org/10.1016/j.ijrobp.2021.02.007. [4] Beukema JC, de Groot C, Plukker JTM, Vliegenthart R, Langendijk JA, van Luijk P, et al. Late cardiac toxicity of neo-adjuvant chemoradiation in esophageal cancer survivors: A prospective crosssectional pilot study. Radiother Oncol 2022;167:72–7. https://doi.org/10.1016/j.radonc.2021.11.029. [5] Jacob S, Pathak A, Franck D, Latorzeff I, Jimenez G, Fondard O, et al. Early detection and prediction of cardiotoxicity after radiation therapy for breast cancer: the BACCARAT prospective cohort study. Radiat Oncol 2016:1–10. https://doi.org/10.1186/s13014-016-0627-5. [6] Beukema JC, van Luijk P, Widder J, Langendijk J a., Muijs CT. Is cardiac toxicity a relevant issue in the radiation treatment of esophageal cancer? Radiother Oncol 2015;114:85–90. https://doi. org/10.1016/j.radonc.2014.11.037. [7] Shapiro J, van Lanschot JJB, Hulshof MCCM, van Hagen P, van Berge Henegouwen MI, Wijnhoven BPL, et al. Neoadjuvant chemoradiotherapy plus surgery versus surgery alone for oesophageal or junctional cancer (CROSS): Long-term results of a randomised controlled trial. Lancet Oncol 2015;16:1090–8. https://doi.org/10.1016/S1470-2045(15)00040-6. [8] Wang X, Bai H, Li R, Wang L, Zhang W, Liang J, et al. High versus standard radiation dose of definitive concurrent chemoradiotherapy for esophageal cancer: A systematic review and metaanalysis of randomized clinical trials. Radiother Oncol 2023;180:109463. https://doi.org/10.1016/j. radonc.2023.109463. [9] Obermannová R, Alsina M, Cervantes A, Leong T, Lordick F, Nilsson M, et al. Oesophageal cancer: ESMO Clinical Practice Guideline for diagnosis, treatment and follow-up. Ann Oncol 2022;33:992– 1004. https://doi.org/10.1016/j.annonc.2022.07.003. [10] Hulshof MCCM, Geijsen ED, Rozema T, Oppedijk V, Buijsen J, Neelis KJ, et al. Randomized Study on Dose Escalation in Definitive Chemoradiation for Patients With Locally Advanced Esophageal Cancer (ARTDECO Study). J Clin Oncol 2021;39:2816–24. https://doi.org/10.1200/JCO.20.03697. [11] Cai G, Li C, Yu J, Meng X. Heart Dosimetric Parameters Were Associated With Cardiac Events and Overall Survival for Patients With Locally Advanced Esophageal Cancer Receiving Definitive Radiotherapy. Front Oncol 2020;10:1–13. https://doi.org/10.3389/fonc.2020.00153. [12] El Haddad D, Iliescu C, Yusuf SW, William WN, Khair TH, Song J, et al. Outcomes of Cancer Patients Undergoing Percutaneous Pericardiocentesis for Pericardial Effusion. J Am Coll Cardiol 2015;66:1119–28. https://doi.org/10.1016/j.jacc.2015.06.1332. [13] Wang X, Palaskas NL, Yusuf SW, Abe J, Lopez-Mattei J, Banchs J, et al. Incidence and Onset of Severe Cardiac Events After Radiotherapy for Esophageal Cancer. J Thorac Oncol 2020. https:// doi.org/10.1016/j.jtho.2020.06.014. [14] Day RW, Jaroszewski D, Chang YHH, Ross HJ, Paripati H, Ashman JB, et al. Incidence and impact of postoperative atrial fibrillation after minimally invasive esophagectomy. Dis Esophagus 2016;29:583–8. https://doi.org/10.1111/dote.12355. [15] Song EY, Venkat P, Fradley M, Frakes JM, Klocksieben F, Fontaine J, et al. Clinical factors associated with the development of postoperative atrial fibrillation in esophageal cancer patients receiving multimodality therapy before surgery 2020;11:68–75. https://doi.org/10.21037/jgo.2019.12.05. [16] Kim KH, Oh J, Yang G, Lee J, Kim J, Gwak SY, et al. Association of Sinoatrial Node Radiation Dose with Atrial Fibrillation and Mortality in Patients with Lung Cancer. JAMA Oncol 2022;8:1624–34. https://doi.org/10.1001/jamaoncol.2022.4202. 8
RkJQdWJsaXNoZXIy MTk4NDMw