130 Chapter 8 [17] Staerk L, Sherer JA, Ko D, Benjamin EJ, Helm RH. Atrial Fibrillation: Epidemiology, Pathophysiology, Clinical Outcomes. Circ Res 2017;120:1501–17. https://doi.org/10.1161/CIRCRESAHA.117.309732. [18] Burstein B, Bs C, Nattel S. Atrial Fibrosis : Mechanisms and Clinical Relevance in Atrial Fibrillation 2008;51. https://doi.org/10.1016/j.jacc.2007.09.064. [19] Schotten U, Verheule S, Kirchhof P, Goette A. Pathophysiological mechanisms of atrial fibrillation: A translational appraisal. Physiol Rev 2011;91:265–325. https://doi.org/10.1152/ physrev.00031.2009. [20]Mery B, Guichard JB, Guy JB, Vallard A, Barthelemy JC, Da Costa A, et al. Atrial fibrillation in cancer patients: Hindsight, insight and foresight. Int J Cardiol 2017;240:196–202. https://doi. org/10.1016/j.ijcard.2017.03.132. [21] Chugh SS, Blackshear JL, Shen WK, Hammill SC, Gersh BJ. Epidemiology and natural history of atrial fibrillation: Clinical implications. J Am Coll Cardiol 2001;37:371–8. https://doi.org/10.1016/ S0735-1097(00)01107-4. [22]Cai G, Li C, Li J, Yang J, Li C, Sun L, et al. Cardiac Substructures Dosimetric Predictors for Cardiac Toxicity After Definitive Radiotherapy in Esophageal Cancer. Int J Radiat Oncol Biol Phys 2023;115:366–81. https://doi.org/10.1016/j.ijrobp.2022.08.013. [23]Van Den Bogaard VAB, Ta BDP, Van Der Schaaf A, Bouma AB, Middag AMH, Bantema-Joppe EJ, et al. Validation and modification of a prediction model for acute cardiac events in patients with breast cancer treated with radiotherapy based on three-dimensional dose distributions to cardiac substructures. J Clin Oncol 2017;35:1171–8. https://doi.org/10.1200/JCO.2016.69.8480. [24]Ghobadi G, Bartelds B, van der Veen SJ, Dickinson MG, Brandenburg S, Berger RMF, et al. Lung irradiation induces pulmonary vascular remodelling resembling pulmonary arterial hypertension. Thorax 2012;67:334–41. https://doi.org/10.1136/thoraxjnl-2011-200346. [25]Ghobadi G, van der Veen S, Bartelds B, de Boer R a, Dickinson MG, de Jong JR, et al. Physiological interaction of heart and lung in thoracic irradiation. Int J Radiat Oncol Biol Phys 2012;84:e63946. https://doi.org/10.1016/j.ijrobp.2012.07.2362. [26]Kroese TE, Jairam J, Ruurda JP, Lin SH, Mohan R, Mook S, et al. Severe lymphopenia acquired during chemoradiotherapy for esophageal cancer: Incidence and external validation of a prediction model. Radiother Oncol 2021;163:192–8. https://doi.org/10.1016/j.radonc.2021.08.009. [27]Li Q, Zhou S, Liu S, Liu S, Yang H, Zhao L, et al. Treatment-Related Lymphopenia Predicts Pathologic Complete Response and Recurrence in Esophageal Squamous Cell Carcinoma Undergoing Neoadjuvant Chemoradiotherapy. Ann Surg Oncol 2019;26:2882–9. https://doi. org/10.1245/s10434-019-07334-7. [28]Dai D, Tian Q, Yu G, Shui Y, Jiang H, Wei Q. Severe Radiation-Induced Lymphopenia Affects the Outcomes of Esophageal Cancer: A Comprehensive Systematic Review and Meta-Analysis. Cancers (Basel) 2022;14:1–15. https://doi.org/10.3390/cancers14123024. [29]Atkins KM, Bitterman DS, Chaunzwa TL, Kozono DE, Baldini EH, Aerts HJWL, et al. Mean Heart Dose Is an Inadequate Surrogate for Left Anterior Descending Coronary Artery Dose and the Risk of Major Adverse Cardiac Events in Lung Cancer Radiation Therapy. Int J Radiat Oncol Biol Phys 2021;110:1473–9. https://doi.org/10.1016/j.ijrobp.2021.03.005. [30]Prunaretty J, Bourgier C, Gourgou S, Lemanski C, Azria D, Fenoglietto P. Different meaning of the mean heart dose between 3D-CRT and IMRT for breast cancer radiotherapy. Front Oncol 2023;12:1–9. https://doi.org/10.3389/fonc.2022.1066915. [31] Noordman BJ, Verdam MGE, Lagarde SM, Hulshof MCCM, Van Hagen P, Van Berge Henegouwen MI, et al. Effect of neoadjuvant chemoradiotherapy on health-Related quality of life in esophageal or junctional cancer: Results from the randomized CROSS trial. J Clin Oncol 2018;36. https://doi. org/10.1200/JCO.2017.73.7718. [32]Pape M, Veen LM, Smit TM, Kuijper SC, Vissers PAJ, Geijsen ED, et al. Late Toxicity and HealthRelated Quality of Life Following Definitive Chemoradiotherapy for Esophageal Cancer: A Systematic Review and Meta-analysis. Int J Radiat Oncol 2023. https://doi.org/10.1016/j. ijrobp.2023.05.025.
RkJQdWJsaXNoZXIy MTk4NDMw