48 Chapter 4 Univariable analysis showed that all lung as well as several cardiac dose parameters were associated with OS. However the high dose pulmonary DVH parameters performed significantly better in predicting this endpoint (suppl. data figure 9). Significant clinical factors for worse OS were high tumour stage, high WHO-score, diabetes mellitus (DM), positive lymph nodes and the use of elective radiotherapy. In the Cox-regression analysis, the V45 of the lungs, DM and tumour stage remained significantly associated with OS. The final model is presented in table 4
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